On the synthesis and processing of high quality audio signals by parallel computers

This work concerns the application of new computer architectures to the creation and manipulation of high-quality audio bandwidth signals. The configuration of both the hardware and software in such systems falls under consideration in the three major sections which present increasing levels of algorithmic concurrency. In the first section, the programs which are described are distributed in identical copies across an array of processing elements; these programs run autonomously, generating data independently, but with control parameters peculiar to each copy: this type of concurrency is referred to as isonomic}The central section presents a structure which distributes tasks across an arbitrary network of processors; the flow of control in such a program is quasi- indeterminate, and controlled on a demand basis by the rate of completion of the slave tasks and their irregular interaction with the master. Whilst that interaction is, in principle, deterministic, it is also data-dependent; the dynamic nature of task allocation demands that no a priori knowledge of the rate of task completion be required. This type of concurrency is called dianomic? Finally, an architecture is described which will support a very high level of algorithmic concurrency. The programs which make efficient use of such a machine are designed not by considering flow of control, but by considering flow of data. Each atomic algorithmic unit is made as simple as possible, which results in the extensive distribution of a program over very many processing elements. Programs designed by considering only the optimum data exchange routes are said to exhibit systolic^ concurrency. Often neglected in the study of system design are those provisions necessary for practical implementations. It was intended to provide users with useful application programs in fulfilment of this study; the target group is electroacoustic composers, who use digital signal processing techniques in the context of musical composition. Some of the algorithms in use in this field are highly complex, often requiring a quantity of processing for each sample which exceeds that currently available even from very powerful computers. Consequently, applications tend to operate not in 'real-time' (where the output of a system responds to its input apparently instantaneously), but by the manipulation of sounds recorded digitally on a mass storage device. The first two sections adopt existing, public-domain software, and seek to increase its speed of execution significantly by parallel techniques, with the minimum compromise of functionality and ease of use. Those chosen are the general- purpose direct synthesis program CSOUND, from M.I.T., and a stand-alone phase vocoder system from the C.D.P..(^4) In each case, the desired aim is achieved: to increase speed of execution by two orders of magnitude over the systems currently in use by composers. This requires substantial restructuring of the programs, and careful consideration of the best computer architectures on which they are to run concurrently. The third section examines the rationale behind the use of computers in music, and begins with the implementation of a sophisticated electronic musical instrument capable of a degree of expression at least equal to its acoustic counterparts. It seems that the flexible control of such an instrument demands a greater computing resource than the sound synthesis part. A machine has been constructed with the intention of enabling the 'gestural capture' of performance information in real-time; the structure of this computer, which has one hundred and sixty high-performance microprocessors running in parallel, is expounded; and the systolic programming techniques required to take advantage of such an array are illustrated in the Occam programming language

NEOimpactor: a tool for assessing Earth's vulnerability to the NEO impact hazard

The Earth’s surface bears the scars of 4.5 billion years of bombardment by asteroids,despite most having been erased by tectonic activity and erosion. Asteroids predominantlyorbit the Sun in the asteroid belt between Mars and Jupiter, but a large numberoccupy orbits close to the Earth’s. These bodies are termed Near Earth Objects (NEOs)and they present a very real impact threat to the Earth. In 1998 NASA inauguratedthe ‘Spaceguard Survey’ to catalogue 90% of NEOs greater than 1 km in diameter. Thesmaller bodies, meanwhile, remain undetected and far more numerous.In order to understand the NEO hazard, the consequences resulting from an asteroidimpact require modelling. While the atmospheric entry of asteroids is a criticalpart of the impact process, it is the surface impact which is most important, both ontoland and into the oceans. It is the impact generated effects (IGEs) that are hazardousto human populations on the Earth and the infrastructure they occupy. By modellingthese IGEs and the consequences they present for humans and infrastructure, anunderstanding of the global vulnerability to the hazard is developed.‘NEOimpactor’ is the software solution built to investigate the global vulnerabilityto NEO impacts. By combining existing mathematical models which describethe impact and effects, a unified impact simulator tool has been developed with thecapacity to model the real consequences of any terrestrial impact.By comparing the consequences of multiple impact events, a complete vulnerabilityassessment of the global NEO hazard is derived. The result maps are designedfor ease of dissemination to explain the impact risk to a non-specialist audience. Thesystem has identified China, US, India, Japan and Brazil as facing the greatest overallrisk, as well as indicating the various factors influencing vulnerability. The results canbe used for informing the international decision making processes regarding the NEOhazard and potential mitigation strategies

Solid tumors of childhood display specific serum microRNA profiles.

BACKGROUND: Serum biomarkers for diagnosis and risk stratification of childhood solid tumors would improve the accuracy/timeliness of diagnosis and reduce the need for invasive biopsies. We hypothesized that differential expression and/or release of microRNAs (miRNAs) by such tumors may be detected as altered serum miRNA profiles. METHODS: We undertook global quantitative reverse transcription PCR (qRT-PCR) miRNA profiling (n = 741) on RNA from 53 serum samples, representing 33 diagnostic cases of common childhood cancers plus 20 controls. Technical confirmation was performed in a subset of 21 cases, plus four independent samples. RESULTS: We incorporated robust quality control steps for RNA extraction, qRT-PCR efficiency and hemolysis quantification. We evaluated multiple methods to normalize global profiling data and identified the 'global mean' approach as optimal. We generated a panel of six miRNAs that were most stable in pediatric serum samples and therefore most suitable for normalization of targeted miRNA qRT-PCR data. Tumor-specific serum miRNA profiles were identified for each tumor type and selected miRNAs underwent confirmatory testing. We identified a panel of miRNAs (miR-124-3p/miR-9-3p/miR-218-5p/miR-490-5p/miR-1538) of potential importance in the clinical management of neuroblastoma, as they were consistently highly overexpressed in MYCN-amplified high-risk cases (MYCN-NB). We also derived candidate miRNA panels for noninvasive differential diagnosis of a liver mass (hepatoblastoma vs. combined MYCN-NB/NB), an abdominal mass (Wilms tumor vs. combined MYCN-NB/NB), and sarcoma subtypes. CONCLUSIONS: This study describes a pipeline for robust diagnostic serum miRNA profiling in childhood solid tumors, and has identified candidate miRNA profiles for prospective testing. IMPACT: We propose a new noninvasive method with the potential to diagnose childhood solid tumors.RCUK, OtherThis is the Author Accepted Manuscript. The final version is available from AACR at http://cebp.aacrjournals.org/content/24/2/350.lon

Probing the Circumgalactic Medium at High-Redshift Using Composite BOSS Spectra of Strong Lyman-alpha Forest Absorbers

We present composite spectra constructed from a sample of 242,150 Lyman-alpha (Lya) forest absorbers at redshifts 2.4<z<3.1 identified in quasar spectra from the Baryon Oscillation Spectroscopic Survey (BOSS) as part of Data Release 9 of the Sloan Digital Sky Survey III. We select forest absorbers by their flux in bins 138 km/s wide (approximately the size of the BOSS resolution element). We split these absorbers into five samples spanning the range of flux -0.05 < F<0.45. Tests on a smaller sample of high-resolution spectra show that our three strongest absorption bins would probe circumgalactic regions (projected separation < 300 proper kpc and |Delta v| < 300km/s) in about 60% of cases for very high signal-to-noise ratio. Within this subset, weakening Lya absorption is associated with decreasing purity of circumgalactic selection once BOSS noise is included. Our weaker two Lya absorption samples are dominated by the intergalactic medium. We present composite spectra of these samples and a catalogue of measured absorption features from HI and 13 metal ionization species, all of which we make available to the community. We compare measurements of seven Lyman series transitions in our composite spectra to single line models and obtain further constraints from their associated excess Lyman limit opacity. This analysis provides results consistent with column densities over the range 14.4 <~ Log (N_HI) <~ 16.45. We compare our measurements of metal absorption to a variety of simple single-line, single-phase models for a preliminary interpretation. Our results imply clumping on scales down to ~30 pc and near-solar metallicities in the circumgalactic samples, while high-ionization metal absorption consistent with typical IGM densities and metallicities is visible in all samples.Comment: 23 pages, 15 figures, 5 tables, link to downloadable data included. Accepted by MNRAS 2014 March 20. New sections 3.4 and 6.1 limiting the occurrence and impact of Lyman limit system

The Effects of the COVID-19 Stay-at-Home Orders on Pain and Mental Health in OMM Patients

New Jersey was placed in a state of emergency and a statewide stay-at-home order during the COVID-19 pandemic Very little has been published examining the effects of chronic pain after stopping osteopathic manipulative medicine (OMM), although it seems unethical to stop a treatment shown to work so well that is both minimally invasive and cost effective We hypothesized OMM patients experienced an increase in pain since the onset of COVID-19 pandemic and closure of OMM/Family Medicine office

Evaluation of a Head-Worn Display System as an Equivalent Head-Up Display for Low Visibility Commercial Operations

Research, development, test, and evaluation of fight deck interface technologies is being conducted by the National Aeronautics and Space Administration (NASA) to proactively identify, develop, and mature tools, methods, and technologies for improving overall aircraft safety of new and legacy vehicles operating in the Next Generation Air Transportation System (NextGen). One specific area of research was the use of small Head-Worn Displays (HWDs) to serve as a possible equivalent to a Head-Up Display (HUD). A simulation experiment and a fight test were conducted to evaluate if the HWD can provide an equivalent level of performance to a HUD. For the simulation experiment, airline crews conducted simulated approach and landing, taxi, and departure operations during low visibility operations. In a follow-on fight test, highly experienced test pilots evaluated the same HWD during approach and surface operations. The results for both the simulation and fight tests showed that there were no statistical differences in the crews' performance in terms of approach, touchdown and takeoff; but, there are still technical hurdles to be overcome for complete display equivalence including, most notably, the end-to-end latency of the HWD system